Welcome to the Antoniak Lab at the UNC Blood Research Center. Our research is driven by a central question: how do viral infections influence coagulation and inflammation, and what determines when these responses protect life—or threaten it?

We investigate the molecular mechanisms linking viral infections, such as influenza A and viral myocarditis, to tissue factor (TF) expression, thrombosis, and immune signaling. By exploring how TF and thrombin-dependent pathways—particularly via protease-activated receptors like PAR4—shape disease outcomes, we aim to better understand both the protective and harmful roles of the body’s response to infection.

Our mission is to uncover how to preserve the life-supporting functions of coagulation while limiting its pathological consequences. Through collaborative, innovative research, we strive to advance knowledge that can lead to improved therapies for viral-induced cardiovascular and pulmonary complications.

Whether you are a student, collaborator, or visitor, we invite you to explore our work and join us in pushing the boundaries of discovery. Get in touch with us to start the journey.